{"id":7258,"date":"2022-01-17T01:42:43","date_gmt":"2022-01-16T21:42:43","guid":{"rendered":"https:\/\/genomics.makotest.site\/c-%e1%83%b0%e1%83%94%e1%83%9e%e1%83%90%e1%83%a2%e1%83%98%e1%83%a2%e1%83%98%e1%83%a1-%e1%83%95%e1%83%98%e1%83%a0%e1%83%a3%e1%83%a1%e1%83%98%e1%83%a1-hcv-pcr-%e1%83%92%e1%83%94%e1%83%9c%e1%83%9d\/"},"modified":"2023-01-27T15:46:06","modified_gmt":"2023-01-27T11:46:06","slug":"mutations-associated-with-the-risk-of-thrombosis","status":"publish","type":"page","link":"https:\/\/genomics.ge\/en\/genetic-research\/mutations-associated-with-the-risk-of-thrombosis\/","title":{"rendered":"Mutations associated with the risk of Thrombosis"},"content":{"rendered":"

Mutations associated with the risk of thrombosis<\/span><\/span><\/h1><\/header><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>
\"bt_bb_section_bottom_section_coverage_image\"<\/div><\/section>
  • About the disease<\/span><\/li>
  • About testing<\/span><\/li>
  • Prevention and treatment<\/span><\/li><\/ul>
    \r\n\t\t\t
    <\/p>\n

    Thrombophilia means a predisposition to thrombosis. It is defined as an abnormality of the coagulation or fibrinolytic system that results in a hypercoagulable state and therefore increases the risk of thrombosis. This pathology has a high risk of pregnancy termination, preeclampsia, placental insufficiency and placental abruption, and recurrent pregnancy loss (RPN). Thrombophilia also increases the risk of venous thromboembolism.\u00a0<\/span><\/p>\n

    There are two types of thrombophilia: genetic (thrombin, Protein S or Protein C deficiency), also called hereditary or congenital, and acquired (antiphospholipid syndrome, nephrotic syndrome).<\/span><\/p>\n

    \n<\/div><\/div>\r\n\t\t<\/div>

    \r\n\t\t\t
    <\/p>\n

    Thrombophilia is diagnosed on the basis of medical history, physical examination and instrumental and laboratory tests.<\/span><\/p>\n

    Genomics, the high-tech biomedical research and genetic diagnostics center provides tests of high accuracy, quality and reliability using the PCR amplification method.<\/span><\/p>\n

    Factor V Leiden (G1691A);
    \nV Factor (H1299R);
    \nFactor II Prothrombin (G20210A);
    \nMTHFR (C677T);
    \nMTHFR (A1298C);
    \nPAI-1 (4G\/5G);
    \nXIII Factor (V34L).<\/p>\n

    \n<\/div><\/div>\r\n\t\t<\/div>

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    <\/p>\n

    In case of confirmed thrombophilia, the basis of thrombosis prevention is a healthy lifestyle, including physical activity, smoking cessation, proper diet and body weight correction.<\/span><\/p>\n

    If thrombophilia is diagnosed and there are additional risk factors for thrombosis, consideration shall be given to medical preventive treatment, administered as anticoagulants or antiplatelet agents as indicated.\u00a0<\/span><\/p>\n

    \n<\/div><\/div>\r\n\t\t<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section>

    Frequently Asked Questions<\/span><\/span><\/h3><\/header>
    <\/div>
    <\/span>
    When should thrombophilia be suspected?<\/div><\/div>
    \n
      \n
    • Thrombosis occurred at a young age (in individuals younger than 50 years), namely, myocardial infarction, ischemic stroke, deep vein thrombosis and pulmonary embolism;\u00a0<\/span><\/li>\n
    • Noteworthy is thrombosis of atypical location (mesenteric vessels,\u00a0 sinus thrombosis etc);<\/span><\/li>\n
    • If a woman has a history of multiple miscarriages, placental insufficiency, pre-eclampsia, and other obstetric pathologies;\u00a0<\/span><\/li>\n
    • A family history of venous thromboembolism deserves attention when thrombosis occurs in first-degree relatives.<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div>
      <\/span>
      What are the symptoms of thrombophilia?<\/div><\/div>
      \n
      \n
      \n
      \n

      It is possible that a person has thrombophilia and for years it does not manifest clinically. Thrombophilia is manifested by thrombosis, the symptoms of which depend on the location of the clot.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>

      <\/span>
      What causes thrombophilia?<\/div><\/div>
      \n

      The causes of thrombophilia include:<\/span><\/p>\n

        \n
      • Changes in the amount or function of proteins involved in blood clotting;<\/span><\/li>\n
      • Antiphospholipid antibody syndrome, which includes three separate antiphospholipid antibodies;<\/span><\/li>\n
      • Disseminated intravascular coagulation (DIC syndrome).<\/span><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/section><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":6908,"parent":7282,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"acf":[],"_links":{"self":[{"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/pages\/7258"}],"collection":[{"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/comments?post=7258"}],"version-history":[{"count":6,"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/pages\/7258\/revisions"}],"predecessor-version":[{"id":7858,"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/pages\/7258\/revisions\/7858"}],"up":[{"embeddable":true,"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/pages\/7282"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/media\/6908"}],"wp:attachment":[{"href":"https:\/\/genomics.ge\/en\/wp-json\/wp\/v2\/media?parent=7258"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}