Thrombophilia means a predisposition to thrombosis. It is defined as an abnormality of the coagulation or fibrinolytic system that results in a hypercoagulable state and therefore increases the risk of thrombosis. This pathology has a high risk of pregnancy termination, preeclampsia, placental insufficiency and placental abruption, and recurrent pregnancy loss (RPN). Thrombophilia also increases the risk of venous thromboembolism.
There are two types of thrombophilia: genetic (thrombin, Protein S or Protein C deficiency), also called hereditary or congenital, and acquired (antiphospholipid syndrome, nephrotic syndrome).